Tenvir or Tenofovir disoproxil, sold under the trade name Viread, medication used to treat HIV/AIDS and chronic hepatitis B. It does not cure HIV/AIDS or hepatitis B. Tenofovir disoproxil can also help decrease a person’s chance of developing AIDS. It is available as a tablet, which can be taken with or without food, and a powder, which should be taken with food.
Common side effects include nausea, rash, diarrhea, headache, pain, depression, and weakness. There are no contraindications to this medication. It should only be used in pregnancy if clearly needed, and women who are taking tenofivir disoproxil are advised to not breast feed. It is a reverse transcriptase inhibitor and works by decreasing the number of viruses in the blood by inhibiting replication.
The drug is on the World Health Organization’s List of Essential Medicines, the most important medications needed in a basic health system. It is marketed by Gilead Sciences (as the fumarate, abbreviated TDF). As of 2015 the cost for a typical month of medication in the United States is more than 200 USD.
Tenofovir disoproxil is generally well tolerated with low discontinuation rates among the HIV and chronic hepatitis B population.There are no contraindications for use of this drug.The most commonly reported side effects due to use of tenofovir disoproxil were dizziness, nausea, and diarrhea. Other adverse effects include depression, sleep disturbances, headache, itching, rash, and fever. The US box warning cautions potential onset of lactic acidosis or liver damage due to use of tenofovir disoproxil.
Long term use of tenofovir disoproxil is associated with nephrotoxicity and bone loss. Presentation of nephrotoxicity can appear as Fanconi syndrome, acute kidney injury, or decline of glomerular filtration rate (GFR). Discontinuation of tenofovir disoproxil can potentially lead to reversal of renal impairment. Nephrotoxicity may be due to proximal tubules accumulation of Tenofovir disoproxil leading to elevated serum concentrations.
What are the side effects of Tenvir-EM?
The most commonly reported side effects when taking Tenvir-EM include: headache, gastrointestinal upset (nausea, diarrhoea, constipation, stomach pain), dizziness, fatigue, rash, difficulty sleeping, abnormal dreams, depression. A more serious but less common side effect is a condition called lactic acidosis which is excess lactic acid in the blood due to liver damage, which may cause pancreatitis, liver failure, or renal failure.
What are the health risks when taking Tenvir-EM?
Lactic acidosis is a rare but potentially fatal condition that has been reported when taking Tenvir-EM tablets. It is caused by a build up of excess of lactic acid in the blood due to liver damage, which is usually associated with hepatomegaly (liver enlargement) with steatosis (build up of fat in the liver) and may cause pancreatitis, liver failure, or renal failure. Symptoms begin within a few months of treatment and include: nausea, vomiting and abdominal pain, difficulty breathing, loss of appetite, weight loss, motor weakness.