Tenofovir is used for:
Treating HIV infection in combination with other medicines. It is also used to treat chronic HBV infection. It may also be used for other conditions as determined by your doctor.
Tenofovir is an antiviral reverse transcriptase inhibitor. It works to treat HIV infection by blocking the growth of HIV. It works to treat HBV infection by blocking the ability of the virus to multiply and infect new liver cells. Tenofovir is not a cure for HIV or HBV.
Tenofovir Disoproxil Fumarate
Tenofovir disoproxil fumarate (tenofovir DF) can cause serious, life-threatening side effects. These include lactic acidosis (buildup of lactic acid in the blood) and severe liver problems.
Contact your health care provider right away if you have any of the following symptoms that could be signs of lactic acidosis:
- Feeling very weak or tired.
- Unusual muscle pain.
- Trouble breathing.
- Stomach pain with either nausea or vomiting.
- Feeling cold, especially in your arms and legs.
- Feeling dizzy or lightheaded.
- Fast or irregular heartbeat.
Contact your health care provider right away if you have any of the following symptoms that could be signs of severe liver problems:
- Yellowing of your skin or the whites of your eyes (jaundice).
- Dark-colored urine.
- Light-colored bowel movements.
- Loss of appetite for several days or longer.
- Stomach pain.
If you have both HIV and hepatitis B virus (HBV) infection and take tenofovir DF, your HBV infection may get much worse (flare up) if you stop taking tenofovir DF. The HBV drug adefovir dipivoxil (brand name: Hepsera) should not be taken with tenofovir DF.
While taking tenofovir DF, it is important to keep all of your appointments with your health care provider.
How to use tenofovir:
Use tenofovir as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with tenofovir. Talk to your pharmacist if you have questions about this information.
- Take tenofovir by mouth with or without food.
- Continue to take tenofovir even if you feel well. Do not miss any doses.
- Taking tenofovir at the same time each day will help you remember to take it.
- Do not suddenly stop taking tenofovir without checking with your doctor. This may cause the virus to become less sensitive to this or other medicines. If you have hepatitis B, your condition could become worse if you suddenly stop taking tenofovir.
- If you miss a dose of tenofovir, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Do NOT use tenofovir if:
- you are allergic to any ingredient in tenofovir
- you have severe liver problems (eg, an enlarged liver) or lactic acidosis
- you take adefovir or other medicines that contain tenofovir
- you take a medicine that may harm your kidneys (eg, an aminoglycoside antibiotic [eg, gentamicin], amphotericin B, cyclosporine, a nonsteroidal anti-inflammatory drug [NSAID] [eg, ibuprofen], tacrolimus, vancomycin). Ask your doctor if you are not sure if any of your medicines might harm your kidneys