Sofovir (Sofosbuvir) is an antiviral medicine that prevents hepatitis C virus (HCV) from multiplying in your body.Sofosvir (Sofosbuvir) is used to treat genotype 1 and genotype 3 chronichepatitis C in adults with or without cirrhosis. MyHep LVIRis given together with another drug called Sovaldi (sofosbuvir).
Sofovir (brand name Sovaldi) is a nucleotide analog used in combination with other drugs for the treatment of hepatitis C virus (HCV) infection. It has been marketed since 2013. Compared to previous treatments, Sofovir -based regimens provide a higher cure rate, fewer side effects, and a two- to four-fold reduced duration of therapy. Sofovir allows most patients to be treated successfully without the use of peginterferon, an injectable drug with severe side effects that is a key component of older drug combinations for the treatment of HCV.
History Of Sofosvir
In 2013, the FDA approved it in combination with ribavirin (RBV) for oral dual therapy of HCV genotypes 2 and 3, and for triple therapy with injected pegylated interferon (pegIFN) and RBV for treatment-naive patients with HCV genotypes 1 and 4. In 2014 a combination of Sofovir with the viral NS5A inhibitor ledipasvir was approved. This latter combination provides high cure rates in people infected with genotype 1 (the most common subtype in the U.S., Japan, and much of Europe) without the use of interferon, irrespective of prior treatment failure or the presence of cirrhosis.
Uses of Sofovir
Sofovir is used for the treatment of chronic hepatitis C, genotypes 1, 2, 3, and 4, in combination with pegylated interferon and ribavirin, or with ribavirin alone. It is also used in combination with the viral NS5a inhibitor ledipasvir in an interferon-free combination for the treatment of genotype 1 hepatitis C infection. Sofovir is also used in HCV patients with an HIV coinfection. The treatment is based on a number of clinical trials, for example the ELECTRON trial which showed that a dual interferon-free regimen of Sofovir plus ribavirin produced a 24-week post-treatment sustained virological response (SVR24) rate of 100% for previously untreated patients with HCV genotypes 2 or 3.
It is a type of drug used to treat Hepatitus C and works on HCV genotypes 1, 2, 3 and 4. Sofosbuvir has to be used in combination with other HCV medications such as Pegylated interferon and Ribavirin.
Uses of Sofovir
Sofovir (Sofosbuvir) is indicated in combination with under medicinal products for the treatment of chronic hepatitis C in genotype 1, 2, 3 and 4. It is suitable to treat patients awaiting liver transplantation and those with HCV/HIV-1 co-infection.
Sofosbuvir directly targets the Hepatitus C virus to stop it from making copies of itself in the liver and makes it harder for the virus to multiply.
Some side effects can be serious. If you have unusual experiences or problems, you should contact your doctor or health care provider immediately.
Dosage and Administration of Sofovir
The recommended dose of Sofovir is one 400mg tablet, taken orally, once daily with or without food. Sofosbuvir should be used in combination with ribavirin or in combination with pegylated interferon and ribavirin for the treatment of chronic hepatitus C (CHC) in adults.
The recommended dosing method in treatment for HCV patients as follows:
1. HCV genotype 1 or 4 takes Sofovir (Sofosbuvir) with Ribavirin and Pegylated interferon for 12 weeks.
2. HCV genotype 2 takes Sofovir (Sofosbuvir) with Ribavirin for 12 weeks (without interferon).
3. HCV genotype 3 takes Sofovir (sofosbuvir with Ribavirin for 24 weeks (without interferon).
(Interferon is injected under the skin, and ribavirin is taken by mouth.)
The above information is only a recommendation, for more details and professional advice, you should check with your doctor or health care provider.
Precautions using Sofovir
- Do not take this Sofovir (Sofosbuvir) alone.
- Using this Sofovir (Sofosbuvir) together with ribavirin while you are pregnant can harm your unborn baby. The combination of Sofovir (Sofosbuvir), Ribavirin and Pegylated interferon can cause serious birth defects. If a pregnancy occurs to mother, while either partners are using these medicines at the time, tell your doctor right away.
- To make sure you are not pregnant, your doctor may ask you to have a pregnancy test before you start using this medicine. You must have a negative pregnancy test before you will be allowed to use this medicine with ribavirin.
- If you are on any other drugs or supplements, breast-feeding, or decide to change dosage or stop taking it, you should discussed with your doctor before hand.